Name: Spinach and Artichoke Chicken Casserole for Cozy Nights
Prep time: 15 min
Cook time: 35 min
Total time: 55 min
Ingredients: 3 cups Cooked Chicken Breasts (use leftover rotisserie chicken for convenience); 2 cups Fresh Baby Spinach (can substitute with kale); 1 cup Artichoke Hearts (frozen can be used if fresh is unavailable); 1 cup Non-Fat Greek Yogurt (can substitute with regular yogurt); 8 oz Light Cream Cheese (regular cream cheese increases calories); 1 cup Shredded Mozzarella Cheese (swap for cheddar if preferred); 1/2 cup Grated Parmesan Cheese (skip if avoiding cheese); 2 cloves Garlic (minced or use garlic powder); to taste Salt & Black Pepper (adjust to taste)

Can you hear the sizzle of your kitchen transforming into a haven of heartwarming aromas? That’s exactly what awaits you with my High-Protein Spinach and Artichoke Chicken Casserole. This comforting dish not only delights with savory chicken and creamy Greek yogurt but also boasts nutrient-packed spinach and tangy artichokes. What’s even better? It’s an easy dinner option that comes together effortlessly—perfect for busy weeknights when you want to rally the family around the table without endless prep. Plus, it reheats beautifully, making it a fantastic choice for meal prep enthusiasts. If you’re ready for a cozy and satisfying experience, let’s dive into how to put this wholesome soul food on your dinner table. Are you as excited to create these comforting layers of goodness as I am?

Why is this casserole a weeknight winner?

Easy Preparation: The steps are simple, making it a breeze to whip up even on the busiest evenings.

High in Protein: Packed with lean chicken and Greek yogurt, it keeps you feeling full and satisfied without excess calories.

Flavorful Comfort: Creamy, cheesy goodness combined with the distinct flavors of spinach and artichokes makes every bite delightful.

Reheats Perfectly: Leftovers taste just as good, perfect for meal prepping or easy lunches throughout the week.

Versatile Options: Feel free to customize the ingredients; swap chicken for turkey or add breadcrumbs for a crunchy topping!

This dish allows you to enjoy hearty comfort food without the fuss, making it a family favorite.

Spinach and Artichoke Chicken Casserole Ingredients

For the Casserole

Cooked Chicken Breasts – This protein source keeps the casserole filling; use leftover rotisserie chicken for convenience.
Fresh Baby Spinach – Adds nutrients and vibrant color; can substitute with kale for a different flavor profile.
Artichoke Hearts – Provides tanginess and texture; frozen artichoke hearts can be used if fresh is unavailable.
Non-Fat Greek Yogurt – Adds creaminess and boosts the protein content; can substitute with regular yogurt for a richer flavor.
Light Cream Cheese – Offers a creamy texture; regular cream cheese may be used for more richness but increases calories.
Shredded Mozzarella Cheese – Adds gooeyness and topping texture; swap for cheddar if preferred.
Grated Parmesan Cheese – Enhances flavor with a salty note; skip if you’re avoiding cheese.
Garlic – Adds aromatic flavor; use garlic powder for a milder taste.
Salt & Black Pepper – Essential for seasoning; adjust to taste based on personal preference.

This Spinach and Artichoke Chicken Casserole is all about wholesome ingredients that create comfort in a dish!

Step‑by‑Step Instructions for Spinach and Artichoke Chicken Casserole

Step 1: Preheat the Oven
Begin by preheating your oven to 375°F (190°C). While the oven heats up, grab a trusty 9×13 inch casserole dish and lightly grease it with cooking spray or olive oil. This ensures your cheese will melt beautifully and doesn’t stick to the sides, making for an easy cleanup later.

Step 2: Prepare the Creamy Base
In a large mixing bowl, combine the non-fat Greek yogurt and light cream cheese until smooth and creamy. Stir in minced garlic, salt, and black pepper, ensuring all the ingredients are well-blended. This mixture will serve as the rich, flavorful base for your Spinach and Artichoke Chicken Casserole and is perfect for providing that satisfying creaminess.

Step 3: Mix in the Filling Ingredients
Next, fold in the shredded cooked chicken, fresh baby spinach, and artichoke hearts into the creamy base. Add half of the shredded mozzarella cheese, mixing gently until everything is thoroughly combined. The colorful ingredients will fill your kitchen with wonderful aromas, signaling that your casserole is coming together nicely!

Step 4: Transfer to the Casserole Dish
Carefully pour the chicken and vegetable mixture into the greased casserole dish, spreading it evenly with a spatula. This step ensures that every bite of your Spinach and Artichoke Chicken Casserole holds a delightful mix of flavors and textures. Smooth the top to create a nice surface for the cheesy topping that will melt and bubble beautifully.

Step 5: Add the Cheese Toppings
Sprinkle the remaining mozzarella cheese generously over the top of the casserole, followed by the grated Parmesan cheese for an extra flavorful kick. The cheese will melt into a gooey blanket, creating a delectable crust that brings the whole dish together. It’s the moment you’ve been waiting for, adding that perfect finishing touch to this comforting meal.

Step 6: Bake to Golden Perfection
Place the casserole in the preheated oven and bake for 30-35 minutes. You’ll know it’s ready when the cheese is bubbly and golden brown, with edges slightly crisped. Keep an eye on it to avoid over-baking; the tempting aroma will have your family gathering in anticipation of a cozy dinner.

Step 7: Cool and Serve
Once baked, remove the Spinach and Artichoke Chicken Casserole from the oven and allow it to cool for about 5 minutes. This brief resting period helps the layers set nicely, making it easier to serve. Use a large spoon to portion out servings and watch as everyone enjoys this delicious, hearty meal that’s sure to become a household favorite!

How to Store and Freeze Spinach and Artichoke Chicken Casserole

Fridge: Store leftover Spinach and Artichoke Chicken Casserole in an airtight container for up to 3 days. This helps maintain its creamy texture and flavors.

Freezer: For longer storage, freeze the casserole in a tightly sealed freezer-safe dish. It can last for up to 3 months. Thaw in the fridge overnight before baking.

Reheating: When ready to enjoy, reheat in the oven at 350°F (175°C) until warmed through, about 20–25 minutes. You can also use the microwave for quick servings, but the oven will keep the cheese from getting rubbery.

Make-Ahead: Prepare the casserole a day in advance, refrigerate, and then bake when ready. This makes it easy to serve a warm, hearty meal without fuss!

What to Serve with High-Protein Spinach and Artichoke Chicken Casserole

Picture a table filled with comforting sides that perfectly complement the rich, creamy layers of your casserole.

Garlic Bread: The crunchy, buttery texture enhances the creamy casserole, perfect for soaking up every delightful bite. A slice offers a warm and inviting addition to the table.
Simple Green Salad: Crisp lettuce, cherry tomatoes, and a light vinaigrette provide a refreshing contrast to the heartiness of the casserole, balancing out the meal beautifully.
Roasted Vegetables: A medley of seasonal veggies adds a burst of flavor and nutrients, making for a visually appealing and hearty side that pairs wonderfully with the chicken casserole.
Quinoa Pilaf: Nutty and fluffy quinoa brings a lovely texture to the meal, plus it’s packed with protein, echoing the casserole’s wholesome essence.
Steamed Broccoli: Bright, tender broccoli adds color and nutrition while its mild flavor complements the rich casserole without overpowering it.
Chardonnay: A glass of chilled Chardonnay provides a light, fruity contrast to the savory layers of the casserole, making it a delightful drink pairing to enjoy.
Apple Crisp: For dessert, this warm, sweet treat provides a perfect finish to your cozy meal, balancing the savory notes with a hint of delightful caramelized flavor.

Spinach and Artichoke Chicken Casserole Variations

Feel free to dive into creativity and make this casserole uniquely yours with delightful twists and substitutions!

Turkey Swap: Replace chicken with shredded turkey, perfect for using up leftovers post-holiday feasts.
Kale Alternative: Substitute spinach with kale for an earthy flavor and added nutritional boost. Its hearty texture holds up beautifully.
Breadcrumb Crunch: Top with a mix of breadcrumbs and Parmesan for a satisfying crunch that adds extra texture to each bite.
Vegan Option: Replace chicken with chickpeas and use vegan cream cheese and yogurt for a plant-based take that’s just as creamy and delicious.
Spicy Kick: Add chopped jalapeños or a dash of cayenne pepper to bring a spicy twist to the comforting flavors.
Herb Infusion: Incorporate fresh herbs like basil or thyme for a fragrant burst—transforming the casserole into an aromatic delight that dances on the palate.
Cheese Lovers: Substitute mozzarella with sharp cheddar or pepper jack for a bolder cheese flavor that elevates the dish.
Extra Veggies: Mix in diced bell peppers or roasted red peppers for an added color and sweetness, enhancing both visual appeal and taste.

For more inspired takes on comfort food, check out my Cottage Cheese Spinach for a lighter option or try the savory goodness of Chicken Waffle Casserole for a fun breakfast twist. Enjoy the creative process, and let your kitchen become a canvas for flavors!

Expert Tips for Spinach and Artichoke Chicken Casserole

Shred Chicken Well: Finely shred your chicken for even distribution, ensuring every bite is packed with flavor and protein.
Perfect Consistency: If using frozen spinach, remember to thaw and squeeze out excess water to avoid a watery casserole.
Let It Rest: Allow the casserole to cool for a few minutes after baking. This helps set the layers, making serving easier and cleaner.
Customize Ingredients: Feel free to swap chicken for turkey or add different cheeses for a personal touch. Experimenting keeps your Spinach and Artichoke Chicken Casserole exciting!
Storage Suggestions: Store leftovers tightly in the fridge for up to 3 days. Reheat in the oven for the best results, keeping the cheesy texture intact.

Make Ahead Options

These Spinach and Artichoke Chicken Casserole are perfect for meal prep enthusiasts! You can prepare the entire casserole up to 24 hours in advance by assembling it in your greased dish, covering it tightly with plastic wrap, and refrigerating until you’re ready to bake. To maintain the casserole’s delicious quality, just add a few extra minutes to the baking time if it goes into the oven cold. If you prefer to prep individual servings, consider dividing the mixture into meal-sized portions that can be stored in airtight containers for up to 3 days. When you’re ready to enjoy, simply reheat it in the microwave or oven until warmed through. This strategy not only saves time on busy weeknights but ensures you have a comforting, homemade dinner ready to go at a moment’s notice!

Spinach and Artichoke Chicken Casserole Recipe FAQs

How should I select fresh spinach for the casserole?
Absolutely! Look for vibrant green, tender leaves without any dark spots or wilting. Fresh baby spinach is preferred for its mild flavor. If the leaves are wilted or have dark blemishes, it’s best to pass and find a fresher bunch.

What’s the best way to store leftovers?
Keep your Spinach and Artichoke Chicken Casserole tightly covered in the refrigerator, and it’ll stay fresh for up to 3 days. I often use airtight containers to maintain its creamy texture and flavor, simply reheat portions in the oven or microwave when you’re ready to enjoy it!

Can I freeze this casserole for later?
Certainly! To freeze your Spinach and Artichoke Chicken Casserole, first let it cool completely. Then, transfer it to a freezer-safe dish, cover it tightly, and it can last for up to 3 months. When ready to eat, thaw it in the refrigerator overnight, then bake until heated to your liking.

What can I do if my casserole is too watery after baking?
If you find your casserole has excess liquid, it could be from not draining the spinach enough or using frozen spinach without squeezing it out first. To troubleshoot, you can return the casserole to the oven and bake for an additional 10-15 minutes uncovered; this helps evaporate some moisture. Next time, be sure to wring out any excess water from frozen spinach!

Are there any dietary considerations I should be aware of?
Very! This casserole contains ingredients like chicken and dairy, which some may need to avoid due to allergies. For a dairy-free option, consider using dairy-free yogurt and cheese alternatives. If you have pets, make sure to keep them away from the casserole, as ingredients like garlic can be harmful to dogs.

Can I make this casserole ahead of time?
Absolutely! You can prepare your Spinach and Artichoke Chicken Casserole a day in advance. Simply assemble the dish, cover it well, and refrigerate. When you’re ready to enjoy a hearty meal, just pop it in the oven to bake, and you’ll have a dreamy dinner without the rush!